Part Number 1492-AAT1: Alpha-1 Antitrypsin (AAT) is a protein that plays a crucial role in the immune system, particularly in the regulation of inflammation and the inhibition of proteolytic enzymes. The protein is encoded by the SERPINA1 gene and is produced primarily by hepatocytes, with its primary function being the inhibition of neutrophil elastase (NE), a proteolytic enzyme that can damage lung tissues.
Technical Specifications
The technical specifications of AAT1 are primarily related to its molecular structure and function. AAT1 is a glycoprotein consisting of a peptide backbone with three N-glycosidically linked oligosaccharides at positions 70, 107, and 271. It has a molecular weight of approximately 52 kDa and is characterized by its ability to bind to proteases, proteins, peptides, and cytokines, as well as interact with cell surface domains.
Alarm/ Error Codes
There are no specific alarm or error codes associated with AAT1 as it is a protein and not an electronic device. However, in the context of alpha-1 antitrypsin deficiency (AATD), a condition characterized by low circulating levels of AAT, certain laboratory values may indicate the presence of the deficiency. These include low serum AAT concentrations, which can be used as an initial screening test, and the presence of specific genotypes, such as the PiZZ genotype.
User Manuals
There are no user manuals specific to AAT1 as it is a protein and not a device that requires manual operation. However, guidelines for the diagnosis and management of AATD are available, including recommendations for laboratory testing and treatment strategies.
Troubleshooting
Troubleshooting for AAT1 is not applicable as it is a protein and not an electronic device. However, in the context of AATD, troubleshooting may involve identifying and addressing the underlying causes of low AAT levels, such as genetic mutations or liver disease, and managing the associated symptoms and complications.
Programming
There is no programming associated with AAT1 as it is a protein and not a device that requires software or algorithmic control. However, research into the regulation of AAT expression and the development of therapeutic strategies for AATD, such as gene therapy or induced pluripotent stem cells, may involve programming and computational modeling.
Installation
There is no installation process for AAT1 as it is a protein produced naturally by the body. However, in the context of AATD, diagnosis and treatment may involve various medical procedures, such as blood tests and liver biopsies, as well as therapeutic interventions like augmentation therapy.